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Ethnic Differences in Carotid Wall Thickness:The Insulin Resistance Atherosclerosis Study Stroke 27:1744-1749, D'Agostino,R.B.,et al, 1996 See this aricle in Pubmed Article Abstract Ethnic differences in cardiovascular disease(CVD)morbidity and mortality have been observed in US adults.However,little data exist on differences in indices of preclinical atherosclerosis such as carotid wall intima- media thickness(IMT)for US non-Hispanic whites,Hispanics,and blacks.This study was undertaken to determine whether there were ethnic differences in carotid wall IMT.Blacks had significantly greater CCA IMT than non- Hispanic whites(865 versus 808um);this remained significant after adjustment for major CVD risk factors and insulin sensitivity(864 versus 823 um).There were no significant differences in ICA IMT between blacks and non-Hispanic whites.Hispanics had significantly lesser CCA IMT than non-Hispanic whites(749 versus 776 um),and these differences remained significant after adjustment for traditional cardiovascular risk factors and insulin sensitivity(750 vs 778 um).There were no significant differences in ICA IMT between non-Hispanic whites and Hispanics.We conclude that ethnic differences exist in CCA but not in ICA IMT in nondiabetic subjects.These differences in IMT,which are indicators of atherosclerosis,are a noninvasive measure that is consistent with some of the data on clinical end points.These differences may be associated with the observed differences in CVD morbidity and mortality among major ethnic groups in the United States.

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(click to filter results - removes previous filter) blacks carotid artery atherosclerosis carotid artery disease carotid artery intima-media thickness cerebrovascular accident,racial differences Hispanics ultrasonography ultrasonography,carotid artery whites

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